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Simultaneous alignment of short reads against multiple genomes
2009
Genome Biology
Genome resequencing with short reads generally relies on alignments against a single reference. GenomeMapper supports simultaneous mapping of short reads against multiple genomes by integrating related genomes (e.g., individuals of the same species) into a single graph structure. It constitutes the first approach for handling multiple references and introduces representations for alignments against complex structures. Demonstrated benefits include access to polymorphisms that cannot be
doi:10.1186/gb-2009-10-9-r98
pmid:19761611
pmcid:PMC2768987
fatcat:3ewhq2vkafb2ff3uh3deqquphe