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During the modern human expansion, new environmental pressures may have driven adaptation, especially in genes related to the perception of ingested substances and their detoxification. Consequently, positive (adaptive) selection may have occurred in genes related to taste, and in those related to the CYP450 system due to its role in biotransformation of potentially toxic compounds. A total of 91 genes (taste receptors and CYP450 superfamily) have been studied using Hierarchical Boosting, adoi:10.1186/s12862-019-1366-7 pmid:30704392 pmcid:PMC6357387 fatcat:uzil25zzq5bzvmd7v2by7eawdq