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Overview Biological researchers increasingly rely on computational models to integrate biological systems knowledge, test hypotheses, and forecast system behavior. The expanding size of these models requires solutions for managing their complexity. Modularity, a time-tested design principle for managing complexity, can be applied within the biological modeling field to parallelize work, automate composition, and promote effective model sharing. As modelers of complex biological systems, we aimdoi:10.1371/journal.pcbi.1003849 pmid:25275523 pmcid:PMC4183381 fatcat:3sb4avxp7ra7tajdynue3denla