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Decision-support systems based on clinical practice guidelines can support physicians and other healthcare personnel in the process of following best practice consistently. A knowledge-based approach to represent guidelines makes it possible to encode computer-interpretable guidelines in a formal manner,perform consistency checks, and use the guidelines directly in decision-support systems.Decision-support authors and guideline users require guidelines in human-readable formats in addition topmid:16779037 pmcid:PMC1560832 fatcat:7tjyizylf5fd7neqc6h2f3q4qu