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Role of FKS Gene in the Susceptibility of Pathogenic Fungi to Echinocandins
Medical Mycology Journal
Echinocandins are antifungal agents that specifically inhibit the biosynthesis of 1,3-β-D-glucan, a major structural component of fungal cell walls. Echinocandins are recommended as first-line or alternative/salvage therapy for candidiasis and aspergillosis in antifungal guidelines of various countries. Resistance to echinocandins has been reported in recent years. The mechanism of echinocandin resistance involves amino acid substitutions in hot spot regions of the FKS gene product, thedoi:10.3314/mmj.18.004 pmid:29848909 fatcat:7bfnfcl2gvaldg2pxu2f7jdsna