Localization of iodine-125-mIP-Des-Met14-bombesin (7-13)NH2 in ovarian carcinoma induced to express the gastrin releasing peptide receptor by adenoviral vector-mediated gene transfer

B E Rogers, M E Rosenfeld, M B Khazaeli, G Mikheeva, M A Stackhouse, T Liu, D T Curiel, D J Buchsbaum
1997 Journal of Nuclear Medicine  
The gastrin releasing peptide receptor (GRPr) has a high affinity for the 14 amino acid bombesin peptide. For this analysis, [125I]-Tyr4-bombesin was compared with [125I]-mIP-bombesin (a seven amino acid bombesin analog) for in vitro binding and internalization into tumor cells and for tumor localization in vivo. Also, a recombinant adenoviral vector (AdCMVGRPr) was used for gene transfer to induce the expression of GRPr in human ovarian cancer cells for binding and tumor localization with these radiolabeled peptides.
pmid:9255155 fatcat:7iozkyqkvvbdpidhzqnli4snjq