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Ifosfamide Encephalopathy and Nonconvulsive Status Epilepticus
Canadian Journal of Neurological Sciences
Abstract:Background:Ifosfamide (IFX), an alkylating agent and isomer of cyclophosphamide, is used as a single agent or a component of multi-agent chemotherapy in the treatment of ovarian, testicular, head and neck cancers, sarcomas and lymphomas. Encephalopathy is manifested by cerebellar ataxia, confusional state, complex visual hallucinations, extrapyramidal signs, seizures, and mutism.Case reports:We report two patients with non-Hodgkin's lymphoma presenting with mutism and confusional statedoi:10.1017/s0317167100120980 fatcat:zehh4dqar5eb3lajy62tghp52i