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Polyubiquitin-dependent recruitment of NEMO/IKKγ into T cell receptor signaling microclusters
The NF-κB essential modulator protein (NEMO) is required for activation of canonical NF-κB by the T cell antigen receptor (TCR). However, the subcellular localization of NEMO during this process is not well understood. By dynamically imaging fluorescent NEMO chimeras in live human T cells, we demonstrate that NEMO is rapidly recruited into TCR microclusters via domains previously implicated in the recognition of linear and K63-linked polyubiquitin. The recruitment of NEMO into TCR microclustersdoi:10.1101/617126 fatcat:tdxzqq3wvjardd4mu3qfs4koe4