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Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress
AbstractOnce disseminated tumor cells (DTCs) arrive at a metastatic organ, they remain there, latent, and become seeds of metastasis. However, the clonal composition of DTCs in a latent state remains unclear. Here, we applied high-resolution DNA barcode tracking to a mouse model that recapitulated the metastatic dormancy of head and neck squamous cell carcinoma (HNSCC). We found that clones abundantly circulated peripheral blood dominated DTCs. Through analyses of multiple barcoded clonaldoi:10.1038/s41598-021-85743-z pmid:33731803 pmcid:PMC7969766 fatcat:ph3yz6cyuzarfiagyoydlutyza