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The role of reactive oxygen and nitrogen species in the development of Fanconi Anemia, an inherited bone marrow failure disorder
2002
The objective of this thesis was to investigate the role of endogenous reactive oxygen and nitrogen species in the pathogenesis of Fanconi's Anemia (FA) using Fanconi Anemia Complementation Group C (Fancc) - deficient mice. This objective was examined in two distinct ways. First, through the generation and characterization of a novel mouse model for FA with intrinsic oxidant stress and secondly, through the observation that nitric oxide (NO) may have a role in cytokine - mediated inhibition of
doi:10.14288/1.0090698
fatcat:cm3j6pufjncsfeimvcpd5sjy6a