Hypoxia-Inducible Factor-1α Promotes Neuroregeneration and Angiogenesis after Cerebral Ischemia

2015 Therapeutic Targets for Neurological Diseases  
To promote neuroregeneration and angiogenesis is a therapeutic target for the treatment of stroke. Hypoxia-inducible factor-1α (HIF-1α) has pleiotropic effects on neurogenesis, angiogenesis and neuroprotection in central nervous system. In this study we investigated whether HIF-1α treatment promotes the proliferation of ischemia induced neural stem cells (NSCs) and neuroregeneration in penumbra. The angiogenesis in penumbra was also investigated. Transient middle cerebral artery occlusion
more » ... ) rat model was used in this study. Rats were divided into 3 groups, Sham group, vehicle group and HIF-lα group. In this study, we found that rats with HIF-1α treatment had better behavioral recovery at day7, 14, 21 and 28 (p<0.05). HIF-lα treatment increased the number of ischemia induced endogenetic NSCs in penumbra obviously (p<0.01). HIF-1α also improved newborn neurons and glial cells in penumbra on the 28 d (p<0.01). HIF-1α treatment promoted expression of erythropoietin (EPO) in peri-ischemic area. Vascular endothelial growth factor (VEGF) expression in HIF-lα group was significantly higher than that in vehicle group (p<0.01). Number of CD 31 positive vascular in penumbra in HIF-lα treatment group was much more than that in vehicle group (p<0.01). In conclusion, our results indicate that modulate HIF-1α after ischemia may be a therapeutic target for the treatment of ischemic stroke through promoting neuroregeneration and angiogenesis.
doi:10.14800/ttnd.719 fatcat:ehxn5zd46rbipibpj7y6wg2aby