Anti-Arrhythmic Effect of Wild Honey Against Catecholamines Cardiotoxicity

Aida A. Hussein ., Miran K. Rakha ., Zohour I. Nabil .
2003 Journal of Medical Sciences  
The present study is a trial to suppress or attenuate the cardiotoxicity of catecholamines, which have been developed synthetically for the treatment of several cardiovascular disorders and conditions such as asthma and nasal congestion. Epinephrine (Adrenaline) is the most commonly available inotrope and in many cases the most appropriate drug t o maintain blood pressure. However, tachycardia, ventricular arrhythmias and hypertension are side effects of this drug. In this investigation,
more » ... on of catecholamines cardiotoxicity was experimentally achieved using epinephrine. In isolated toads'hearts, the cardiac arrhythmias produced by different concentrations of epinephrine (10, 50, 100, 200 and 300 ng mlG ) 1 included extrasystoles, tachyarrhythmias and bradyarrhythmias as well as abnormalities of both P-wave and ST segment. Application of wild honey (0.5 g mlG ) nearly managed t o 1 counteract these effects. These results suggest that wild honey may be useful in the treatment of some cardiac arrhythmias, especially which are associated with hyper-adrenergic activity.
doi:10.3923/jms.2003.127.136 fatcat:hau6w6752zh5fa65rqfcjpc35q