Achieving High-Resolution 1H-MRSI of the Human Brain with Compressed-Sensing and Low-Rank Reconstruction at 7 Tesla

Antoine Klauser, Bernhard Strasser, Bijaya Thapa, Francois Lazeyras, Ovidiu Andronesi
2021 Journal of magnetic resonance (San Diego, Calif. 1997 : Print)  
Low sensitivity MR techniques such as magnetic resonance spectroscopic imaging (MRSI) greatly benefit from the gain in signal-to-noise provided by ultra-high field MR. High-resolution and whole-slab brain MRSI remains however very challenging due to lengthy acquisition, low signal, lipid contamination and field inhomogeneity. In this study, we propose an acquisition-reconstruction scheme that combines 1H free-induction-decay (FID)-MRSI sequence, short TR acquisition, compressed sensing
more » ... ion and low-rank modeling with total-generalized-variation constraint to achieve metabolite imaging in two and three dimensions at 7 Tesla. The resulting images and volumes reveal highly detailed distributions that are specific to each metabolite and follow the underlying brain anatomy. The MRSI method was validated in a high-resolution phantom containing fine metabolite structures, and in five healthy volunteers. This new application of compressed sensing acceleration paves the way for high-resolution MRSI in clinical setting with acquisition times of 5 min for 2D MRSI at 2.5 mm and of 20 min for 3D MRSI at 3.3 mm isotropic.
doi:10.1016/j.jmr.2021.107048 pmid:34438355 pmcid:PMC8717865 fatcat:pfidjvdn4rcklaqnsgcgz2gfea