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Objective: To investigate whether higher fasting serum glucose levels in cognitively normal, nondiabetic adults were associated with lower regional cerebral metabolic rate for glucose (rCMRgl) in brain regions preferentially affected by Alzheimer disease (AD). Methods: This is a cross-sectional study of 124 cognitively normal persons aged 64 6 6 years with a first-degree family history of AD, including 61 APOEe4 noncarriers and 63 carriers. An automated brain mapping algorithm characterized anddoi:10.1212/wnl.0b013e31828f17de pmid:23535495 pmcid:PMC3662330 fatcat:enlmgrrcvrhkfgocbei53ccq44