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Comprehensive Review of the Relative Clinical Utility of B-Type Natriuretic Peptide and N-Terminal Pro-B-Type Natriuretic Peptide Assays in Cardiovascular Disease
Open Heart Failure Journal
Measurable B-type natriuretic peptides, which are largely produced by the left ventricle, include B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP). These proteins are released by cardiomyocytes in response to wall-tension and neurohumoral signals. In this review the literature is summarized to date with respect to the approved indications for testing which include the diagnostic evaluation and prognosis of heart failure. PubMed in 2009 was searched anddoi:10.2174/1876535100902010006 fatcat:2gnuwnratvgrpmzrca57xmyg2a