Coronary artery atherectomy reduces plaque shear strains: An endovascular elastography imaging study

Zahra Keshavarz-Motamed, Yoshifumi Saijo, Younes Majdouline, Laurent Riou, Jacques Ohayon, Guy Cloutier
2014 Atherosclerosis  
Mechanical response and properties of the arterial wall can be used to identify the biomechanical instability of plaques and predict their vulnerability to rupture. Shear strain elastography (SSE) is proposed to identify vulnerable plaque features attributed to mechanical structural heterogeneities. The aims of this study were: 1) to report on the potential of SSE to identify atherosclerotic plaques; and 2) to use SSE maps to highlight biomechanical changes in lesion characteristics after
more » ... ional coronary atherectomy (DCA) interventions. For this purpose, SSE was imaged using in vivo intravascular ultrasound (IVUS) radio-frequency data collected from 12 atherosclerotic patients before and after DCA intervention. Coronary atherosclerotic plaques (pre-DCA) showed high SSE magnitudes with large affected areas. There were good correlations between SSE levels and soft plaque content (i.e., cellular fibrosis, thrombosis and fibrin) (mean jSSEj vs. soft plaque content: r ¼ 0.82, p < 0.01). Significant differences were noticed between SSE images before and after DCA. Stable arteries (post-DCA) exhibited lower values than pre-DCA vessels (e.g., pre-DCA: mean jSSEj ¼ 3.9 AE 0.2% vs. 1.1 AE 0.2% post-DCA, p < 0.001). Furthermore, SSE magnitude was statistically higher in plaques with a high level of inflammation (e.g., mean jSSEj had values of 4.8 AE 0.4% in plaques with high inflammation, whereas it was reduced to 1.8 AE 0.2% with no inflammation, p < 0.01). This study demonstrates the potential of the IVUS-based SSE technique to detect vulnerable plaques in vivo.
doi:10.1016/j.atherosclerosis.2014.04.022 pmid:24835433 fatcat:huvl75el4ff4vgd6vvgpvkhqbi