Nodular hyperplasia of thyroid glands induced by thiouracil

1949 Cancer Research  
The prolonged administration of antithyroid compounds provides an experimental means by which the activity of endogenous pituitary thyro tropic hormone may be studied. The mechanism of action of these agents supposedly involves the in hibition of thyroid hormone formation, thus re moving the controlling activity of the thyroid hormone upon the thyrotropic hormone of the anterior hypophysis (1, 92,13, 14, 927, 34, 35) . A number of agents have been found which in duce diffuse and nodular
more » ... sia of the thy roid gland in rats by this mechanism. This is im portant because spontaneous thyroid tumors are Kuzell of the Department of Pharmacology for the privilege of studying his animals.
pmid:18115920 fatcat:scytpztolndmtki7ivnyt2soma