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Interdependence, Reflexivity, Fidelity, Impedance Matching, And The Evolution Of Genetic Coding
[article]
2017
bioRxiv
pre-print
Genetic coding is generally thought to have required ribozymes whose functions were taken over by polypeptide aminoacyl-tRNA synthetases (aaRS). Two discoveries about aaRS and their tRNA substrates now furnish a unifying rationale for the opposite conclusion: that the key processes of the Central Dogma of molecular biology emerged simultaneously and naturally from simple origins in a peptide·RNA partnership, eliminating the epistemological need for a prior RNA world. First, the two aaRS classes
doi:10.1101/139139
fatcat:4zjrchsyxzejfkqivoqv7iq7gu