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The invention of reactions useful for the synthesis of specifically fluorinated natural products
1977
Pure and Applied Chemistry
Hypofluorites, especially CF30F and CF2(0F)2, are useful positive fluorine reagents, Addition to double bonds, aromatic Substitution and N-fluorination are amongst the processes studied. In recent werk the remarkable capacity of CF 3 0F and F 2 to substitute electrophilically tertiary hydrogen to give (with retention) tertiary fluoro-compounds has been discovered. This reaction is very sensitive to electronegative substituents, It shows unprecedentedregiospecificity and makes available readily 9aand 14afluoro-steroids,
doi:10.1351/pac197749091241
fatcat:vswkstzr4bh6pjbzkrglii42nq