Methotrexate for refractory prurigo nodularis

Mariam Al Al Zaabi, Mohammad Al Al Suwaiji, Manal Nasir
2017 Nasza Dermatologia Online  
Prurigo nodularis (PN) is chronic unbearable inflammatory skin disease. Although it was described before a century, not many studies have been conducted regarding the systemic treatment of prurigo nodularis. A 64-year-old male patient has moderate to severe atopic dermatitis superimposed by disseminated pruritic nodules over the trunk and extremities. In spite of topical treatment and Phototherapy, patient condition was deteriorating. Therefore, the patient was treated with multimodalities
more » ... ultimodalities including high potency topical steroid, intravenous antihistamine, cyclosporine and omalizumab without improvement. Thus the patient has been treated with methotrexate which led to remarkable improvement. Management of prurigo nodularis is often challenging as the etiology of PN in the majority of the cases is unknown. Conservative treatments are often inefficient. This case proves the efficacy of methotrexate in the management of prurigo nodularis.
doi:10.7241/ourd.20171.10 fatcat:xlxhjxn63vhr7djdcqhv4fzv6e