Role of Orexin in Reproductive System

Abdinasir Isse, Yue-Hong Tao, Waleed Naji, Sami Ullah
2017 IOSR Journal of Dental and Medical Sciences  
Orexins (OX), OX-A and OX-B, were initially identified as hypothalamic neuropeptides primarily involved in the control of food intake and states of arousal. Thereafter, orexins have been substantiated as putative pleiotropic regulators of a wide diversity of biological systems, including different neuroendocrine axes. Among the latter, compelling experimental evidence has recently been documented that orexins, mainly OX-A, may act at different levels of the hypothalamic-pituitary-gonadal (HPG)
more » ... tary-gonadal (HPG) axis to modulate reproductive function. However, orexin neurons are "multi-tasking" neurons that regulate sleep/wake states as well as feeding behavior, emotion, and reward processes. Orexin deficiency causes abnormalities in energy homeostasis, stress-related behavior, and reward systems. Male sexual behavior is altered by orexin receptor-1 agonists or antagonists, suggesting a role for orexin-A in this naturally rewarding behavior. However, the specific role of endogenous orexin-A or B in different elements of male sexual behavior is currently unclear. Therefore this review aims to explain the role of orexin in male and female reproductive system.
doi:10.9790/0853-160309122124 fatcat:dnxcmgpornhi7kd35bppfqq3j4