A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is
Action potentials in pyramidal neurons are typically followed by an afterdepolarization (ADP), which in many cells contributes to intrinsic burst firing. Despite the ubiquity of this common excitable property, the responsible ion channels have not been identified. Using current-clamp recordings in hippocampal slices, we find that the ADP in CA1 pyramidal neurons is mediated by an Ni 2ϩ -sensitive calcium tail current. Voltage-clamp experiments indicate that the Ni 2ϩ -sensitive current has adoi:10.1523/jneurosci.0624-05.2005 pmid:15958743 fatcat:tembjtr7wrfifoddeaa4g6rx2e