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Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA damage repair, and genomic stability. The purpose of this study was to characterize WWOX expression in spontaneous canine mast cell tumors (MCTs) and malignant cell lines and investigate the potential contribution of WWOX loss on malignant mast celldoi:10.21203/rs.3.rs-25520/v1 fatcat:hwhxyld7rnfirpjs5lelqan4cq