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RETRACTED: Structure of the Parathyroid Hormone Receptor C Terminus Bound to the G-Protein Dimer Gβ1γ2
2008
Structure
A critical role of the Gbg dimer in heterotrimeric G-protein signaling is to facilitate the engagement and activation of the Ga subunit by cell-surface Gprotein-coupled receptors. However, high-resolution structural information of the connectivity between receptor and the Gbg dimer has not previously been available. Here, we describe the structural determinants of Gb 1 g 2 in complex with a C-terminal region of the parathyroid hormone receptor-1 (PTH1R) as obtained by X-ray crystallography. The
doi:10.1016/j.str.2008.04.010
pmid:18611381
pmcid:PMC2601695
fatcat:g7ki6db6jjgd5oaoqzybf2p6dy