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Diterpenoids from the Soft Coral Sinularia maxima and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells

Nguyen Phuong Thao, Nguyen Hoai Nam, Nguyen Xuan Cuong, Tran Hong Quang, Pham The Tung, Bui Huu Tai, Bui Thi Thuy Luyen, Doobyeong Chae, Sohyun Kim, Young-Sang Koh, Phan Van Kiem, Chau Van Minh (+1 others)
2012 Chemical and pharmaceutical bulletin  

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Nine new diterpenoids, termed sinumaximols A-I (1-3, 5-9, 12), together with three known compounds (4, 10, 11), were isolated from the methanol extract of the soft coral Sinularia maxima. Their structures were elucidated on the basis of extensive spectroscopic methods, including one-dimensional (1D) and twodimensional (2D) nuclear magnetic resonance (NMR) and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). The isolated compounds were evaluated for their inhibitory
more » ... s on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs). Among them, compounds 2, 3, and 11 were potent inhibitors of LPS-stimulated interleukin-12 (IL-12) p40 with half-maximal inhibitory concentration (IC 50 ) values ranging from 4.35 0.12 to 18.04 0.21 µM. Compounds 2, 3, and 11 showed moderate inhibitory activity on IL-6 production with IC 50 values ranging from 17.72 0.31 to 59.77 2.34 µM.
doi:10.1248/cpb.c12-00756 pmid:23207638 fatcat:6lolsalc75f4rl7qvni2wjkvmi
Citation

Nguyen Phuong Thao, Nguyen Hoai Nam, Nguyen Xuan Cuong, Tran Hong Quang, Pham The Tung, Bui Huu Tai, Bui Thi Thuy Luyen, Doobyeong Chae, Sohyun Kim, Young-Sang Koh, Phan Van Kiem, Chau Van Minh, Young Ho Kim. "Diterpenoids from the Soft Coral Sinularia maxima and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells." Chemical and pharmaceutical bulletin 60.12 (2012) 1581-1589