Neonatal Cerebral Sinovenous Thrombosis

Karina J. Kersbergen, Floris Groenendaal, Manon J. N. L. Benders, Linda S. de Vries
2011 Journal of Child Neurology  
Neonates are known to have a higher risk of cerebral sinovenous thrombosis than children of other age groups. The exact incidence in neonates remains unknown and is likely to be underestimated, as clinical presentation is nonspecific and diagnosis can only be made when dedicated neuroimaging techniques, including computed tomographic venography or magnetic resonance venography, are performed. Associated intracranial lesions are common and some, such as a unilateral thalamic hemorrhage, should
more » ... ggest cerebral sinovenous thrombosis as the underlying etiology. Neurodevelopmental outcome is poor in about 50% of these infants and is adversely affected by associated parenchymal lesions. Anticoagulation therapy will limit propagation of the clot and possibly the development or enhancement of parenchymal lesions. Multicenter randomized clinical trials are urgently needed to address many of these important issues.
doi:10.1177/0883073811408090 pmid:21693652 pmcid:PMC3674555 fatcat:lluyva2eyrhhxh36hb2375kq4u