Thirty-one patients with advanced paranasal sinus carcinomas received by "two-route" intra-arterial chemotherapy using cis-diamminedichloroplatinum (CDDP) and sodium thiosulfate (STS) to preserve the hard palate and the eye. In these patients, 100 or 150mg/m2 of CDDP was administered weekly through each feeding artery of the tumor superselectively at a rate of 5 mg/min. During the CDDP infusion, a dosage of STS that was two-hundred fold times larger than the CDDP dasage was injected through a

more »

... theter placed in the brachiocephic vein, introduced via the subclavian vein. The complete and partial response rates were 24/31 (77%) and 7/31 (22%), respectively. Twenty-six patients were treated through the femoral artery, eight patients were through the superficial temporal artery and three were through both the femoral and the superficial temporal arteries. The overall survival rate for untreated stage III and IV carcinomas was calculated by the Kaplan-Meier method to be 80%. Of the sixteen patients with orbital fat and/or musculature invasions, the orbital contents were preserved in 14 patients. CT -arteriography is a very efficient method for the visualization of feeding arteries into paranasal sinus cancers. Each weekly chemotherapy treatment was performed on schedule. This new method of chemotherapy appears to be very effective for advanced paranasal sinus carcinomas.