Case Report Systemic lupus erythematosus in children (childhood onset SLE/cSLE) have a great variability in disease presentation. Any organ system can be involved in cSLE leading to protean clinical manifestations. In this case report, we present a 11-year-old Bangladeshi girl who presented with inflammatory pain in multiple joints, high-grade intermittent fever, headache, high blood pressure, and generalized tonic-clonic seizures. Detailed clinical examination with laboratory and imaging

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... s clinched the diagnosis of SLE and the involved organs include skin, mucosa, joint, haemopoietic system, kidney, and brain. In presenting this case and reviewing the literature, we emphasize the importance of very high index of suspicion for diagnosis of cSLE for early diagnosis, treatment and meticulous monitoring.