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Structural and Thermodynamic Approach to Peptide Immunogenicity
2008
PLoS Computational Biology
In the conventional paradigm of humoral immunity, B cells recognize their cognate antigen target in its native form. However, it is well known that relatively unstable peptides bearing only partial structural resemblance to the native protein can trigger antibodies recognizing higher-order structures found in the native protein. On the basis of sound thermodynamic principles, this work reveals that stability of immunogenic proteinlike motifs is a critical parameter rationalizing the diverse
doi:10.1371/journal.pcbi.1000231
pmid:19023401
pmcid:PMC2577884
fatcat:ghip7io2hrhd5ay75yeexkyg7i