Soluble CD40L and Cardiovascular Risk in Asymptomatic Low-Grade Carotid Stenosis

S. Novo, S. Basili, R. Tantillo, A. Falco, V. Davi, G. Novo, E. Corrado, G. Davi
2005 Stroke  
and Purpose-We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques. Methods-Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8
more » ... edian follow-up, 8 years). Results-ALCS patients had higher (PϽ0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels (Pϭ0.003) independently predicted cardiovascular risk. Conclusions-High levels of sCD40L may predict the risk of CV events in ALCS. (Stroke. 2005;36:673-675.)
doi:10.1161/01.str.0000154878.58398.14 pmid:15677577 fatcat:qjohy24wbrg2rk34oigyukijpq