A neurodevelopmental basis for BECTS: Evidence from structural MRI

Heath R. Pardoe, Anne T. Berg, John S. Archer, Robert K. Fulbright, Graeme D. Jackson
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/i5cvc2xxg5cvjfxxwkvdlht5zy" style="color: black;">Epilepsy Research</a> </i> &nbsp;
Purpose-BECTS (benign epilepsy with centro-temporal spikes) is one of the most common childhood-onset epilepsy syndromes. We investigated quantitative evidence for brain morphological variation associated with BECTS to provide insights into the neuroanatomical basis of this disorder. Methods-Three independent BECTS groups were imaged at different stages: (a) near onset (n = 16, mean age 9.3 ± 1.6 years), (b) ~9 years after onset (n = 9, mean age 15.8 ± 2.3 years), and (c) 15 years after onset
more &raquo; ... = 10, mean age 22.7 ± 2.7 years). Age-matched controls were imaged with each group. Whole brain T1-weighted MRI was acquired. Voxel-based morphometry (groups a-c) and cortical thickness analyses (groups b and c) were undertaken within each group and for the groups combined. The relationship between cortical morphology and age was investigated.
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