RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan

Sangsoon Park, Yoonji Jung, Seon Woo A. An, Heehwa G. Son, Wooseon Hwang, Dongyeop Lee, Murat Artan, Hae-Eun H. Park, Dae-Eun Jeong, Yujin Lee, Seung-Jae V. Lee
2017 F1000Research  
α-arrestins are a family of proteins that are implicated in multiple Background: biological processes, including metabolism and receptor desensitization. Here, we sought to examine the roles of α-arrestins in the longevity Methods: of through an RNA interference screen. We Caenorhabditis elegans Results: found that knocking down each of 24 out of total 29 α-arrestins had C. elegans small or no effects on lifespan. Thus, individual α-arrestins may C. elegans have minor effects on longevity. This
more » ... study will provide useful Conclusions: information for future research on the functional role of α-arrestins in aging and longevity.
doi:10.12688/f1000research.12337.2 pmid:29123644 pmcid:PMC5657022 fatcat:kkvle63gnffmtgvsujkih3rcau