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α-arrestins are a family of proteins that are implicated in multiple Background: biological processes, including metabolism and receptor desensitization. Here, we sought to examine the roles of α-arrestins in the longevity Methods: of through an RNA interference screen. We Caenorhabditis elegans Results: found that knocking down each of 24 out of total 29 α-arrestins had C. elegans small or no effects on lifespan. Thus, individual α-arrestins may C. elegans have minor effects on longevity. Thisdoi:10.12688/f1000research.12337.2 pmid:29123644 pmcid:PMC5657022 fatcat:kkvle63gnffmtgvsujkih3rcau