Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression

Guilherme Freire Garcia, Alexandre Sampaio Moura, Cid Sérgio Ferreira, Manoel Otávio da Costa Rocha
2007 Revista da Sociedade Brasileira de Medicina Tropical  
Medical charts and radiographs from 38 HIV-infected patients with positive cultures for Mycobacterium tuberculosis from sputum or bronchoalveolar lavage were reviewed in order to compare the clinical, radiographic, and sputum bacilloscopy characteristics of HIV-infected patients with pulmonary tuberculosis according to CD4+ lymphocyte count (CD4). The mean age of the patients was 32 years and 76% were male. The median CD4 was 106 cells/mm³ and 71% had CD4 < 200 cells/mm³. Sputum bacilloscopy
more » ... positive in 45% of the patients. Patients with CD4 < 200 cells/mm³ showed significantly less post-primary pattern (7% vs. 63%; p = 0.02) and more frequently reported weight loss (p = 0.04). Although not statistically significant, patients with lower CD4 showed lower positivity of sputum bacilloscopy (37% vs. 64%; p = 0.18). HIV-infected patients with culture-confirmed pulmonary tuberculosis had a high proportion of non-post-primary pattern in thoracic radiographs. Patients with CD4 lower than 200 cells/mm³ showed post-primary patterns less frequently and reported weight loss more frequently.
doi:10.1590/s0037-86822007000600004 pmid:18200412 fatcat:57mkrukj6zh5vodcpzptdvkpzy