T Cell Epitope-Based Vaccine Design for Pandemic Novel Coronavirus 2019-nCoV [post]

Dr. Seema Mishra
2020 unpublished
Immunoinformatics approach has been used to identify potential T cell epitopes from structural and non-structural proteins for immunotherapy against novel coronavirus 2019-nCoV across populations Two different prediction algorithms, NetCTLpan and Pickpocket were used to generate consensus epitopes against HLA supertypes. All of the 57 epitopes identified had no similarity/identity with the human proteome thus preventing crossreactivity. Many of these epitopes formed a tight cluster around
more » ... sus sequences <p>MGYINVFAFPFTIYSLLLC and KVSIWNLDYIINLI across proteins and alleles. These should be urgently tested in <i>in-vitro</i> MHC binding and T cell assays before being tried as vaccines to further prevent pandemic due to this lethal coronavirus.<br></p>
doi:10.26434/chemrxiv.12029523 fatcat:iyah3anvbzdybbcsiy2f4ftahy