Vaccination is the administration of a vaccine to help the immune system develop protection from disease. It is the most effective method of preventing infectious diseases. The objective of the study was to assess vaccination coverage and show the habit and reluctance of the population on vaccination. This was a prospective and descriptive study from May 18 th 2017 to November 30 th 2017 about evaluation of vaccination coverage for children aged 12-23 months admitted in N'Djamena Mother and

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... d University hospital. Patients were recruited after checking the vaccination card and getting the consent by parent. Three hundred forty five children aged 12-23 months and their parents were recruited. There were 201 boys (58.25%) for 144 girls (41.75%) giving a sex ratio of 1.4.The mothers with secondary level schooling were more represented with 34.78%. Children that had received oral polio vaccine 1 and the pentavalent1 were more represented. Long distance was the first reason of no vaccination (18.68%). The majority of mothers (53.04%) had known the five vaccination meeting and recognized by the national program of vaccination. One hundred forty six mothers (45, 21%) thought that it must happens a week after the birth. Measles was known by 34.90% of mothers. Fever was the most reported vaccine's side effects in 87.50%. Vaccination coverage in N'Djamena Mother and Child University hospital is similar to those of Africans authors.