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Calcium and neurodegeneration
2007
Aging Cell
When properly controlled, Ca 2+ fluxes across the plasma membrane and between intracellular compartments play critical roles in fundamental functions of neurons, including the regulation of neurite outgrowth and synaptogenesis, synaptic transmission and plasticity, and cell survival. During aging, and particularly in neurodegenerative disorders, cellular Ca 2+ -regulating systems are compromised resulting in synaptic dysfunction, impaired plasticity and neuronal degeneration. Oxidative stress,
doi:10.1111/j.1474-9726.2007.00275.x
pmid:17328689
fatcat:umjy5jhsufglrdb2fm5ezbdmcq