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Differential modulation of ventral tegmental area circuits by the nociceptin/orphanin FQ system
The neuropeptide nociceptin/orphanin FQ (N/OFQ) system can be activated under conditions of stress and is associated with disorders of emotional regulation and reward processing. N/OFQ and its cognate receptor, NOP, are highly enriched in dopaminergic pathways, and intra-ventricular agonist delivery decreases dopamine levels in the dorsal striatum, nucleus accumbens (NAc), and the ventral tegmental area (VTA). We used whole cell electrophysiology in acute rat brain slices to investigatedoi:10.1101/776484 fatcat:qsglfs65cfggdacdtcurqudbii