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fused to digest food, and I was starving in a land of plenty. 1 became irritable in the extreme, restless, wretched and miserable, with a strong desire to go I knew not where, any where if I could but get rid of myself. I suffered constantly from restless and disturbed sleep. The effect upon the action of the heart was most direful, causing a convulsed and irregular action. At times, worn out with its labored action, it would scarcely beat at all, thereby causing great depression of spirits.doi:10.1056/nejm184604080341004 fatcat:kcmtytxgo5dlfcqv4ul2hf5yt4