TO STUDY ZINC DEFICIENCY AS A RISK FACTOR FOR FEBRILE CONVULSIONS
Journal of Evolution of Medical and Dental Sciences
BACKGROUND Febrile seizure is the most common type of seizure that affects children under 5 years of age. Micronutrient deficienc ies like zinc deficiency, have been linked with febrile seizures in children. We wanted to determine the correlation between zinc deficiency and febrile seizures in children aged between 6 months and 6 years of age. METHODS This case control study was held in a tertiary care centre in 2013. 75 children aged 6 months to 60 months with first/recurrent episode of
... t episode of febrile seizures constituted the cases. Age and sex matched controls with non-seizure febrile illness were taken as controls. Zinc levels in both groups were compared. RESULTS Mean serum zinc levels among the febrile seizure group [54.53 mcg/dl] was much lesser than that in control group [89.88 mcg/dl] and the difference was statistically significant with p value of <0.05. CONCLUSION Hypozincaemia was observed in children with febrile seizures. However large prospective trials are needed to confirm the association. HOW TO CITE THIS ARTICLE: Subbarao P, Apoorva PS, Kathiravan K, et al. To study zinc deficiency as a risk factor for febrile convulsions. BACKGROUND The International League Against Epilepsy [ILAE] defines a febrile seizure [FS] as a seizure occurring in childhood after one month of age, associated with a febrile illness which is not due to infection of the central nervous system. FS are the most common; 2 to 5% of children younger than 5 years of age with peak incidence in the second year of life. 1 FS are common between 6 months to 5 years of age with febrile episodes, that are not associated with any central nervous system infection or any metabolic abnormalities and without history of previous afebrile seizures. 2 Aetiology of febrile seizures includes bacterial and viral infections, 3 vulnerability of the immature brain to fever, 4 association with interleukins, circulatory toxins, 5 trace element deficiency, iron deficiency 6 and role of genetics as triggering factor. Some elements because of their coenzyme activity and their impact on receptors and ion channels, understood to have an important role in febrile seizures.