DESIGN AND FORMULATION OF METOPROLOL SUCCINATE EXTENDED RELEASE ORAL TABLETS BY USING XANTHAN GUM AND HPMC K 100M AS MATRIX CARRIERS

V Ramesh, Y Vardhani, B Nagendra Babu, P Praveen Srikumar, Mr Ramesh
2015 International Journal of Trends in Pharmacy and Life Sciences   unpublished
Metoprolol succinate is an Anti-hypertensive drug belongs to class I under BCS classification and recommended initial dosage is 25-100mg administered once daily. The objective of the present study was to formulate metoprolol succinate extended release matrix tablets using xanthan gum (natural polymer) and to elucidate the release kinetics of Metoprolol Succinate from xanthan gum-matrices. Here, an attempt was made to develop Metoprolol Succinate extended release matrix formulations X1A,
more » ... ations X1A, X1B,X1C, were developed by using xanthan gum, MCC PH 102, HPMC 5 CPS and HPMC K 100 M by dry granulation, direct compression, wet granulation. Eleven extended release formulations [X1-X10] were developed by using varying proportions of xantham gum, MCC PH 102, HPMC 5 CPS and HPMC K 100 M by wet granulation. The physiological and In vitro release characteristics of all formulations were investigated and compared ten formulations X2, X3, X4, X5, X6, X7, X7 EG1, X8, X9, X10 have shown not more than 20%. Drug release in first hour 20%-40% drug release at 4th hour, 40%-70% drug release at 8th hour and not less than 80% at 20th hour and release pattern confirm with USP specifications for 24hrs extended release formulation. By evaluating above formulas conclusively stated that optimum concentration of HPMC K 100M (X8) formulation by wet granulation method seemed to be close to the innovator's release profile. Then similarity factor was calculated between formulation X-8 and innovator. Similarity factor was 80, so formulation X-8 has similar release profile to the marketed formulation release.
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