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Vasoregression is a common phenomenon underlying physiological vessel development as well as pathological microvascular diseases leading to peripheral neuropathy, nephropathy, and vascular oculopathies. In this review, we describe the hallmarks and pathways of vasoregression. We argue here that there is a parallel between characteristic features of vasoregression in the ocular microvessels and atherosclerosis in the larger vessels. Shared molecular pathways and molecular effectors in the twodoi:10.1089/omi.2015.0128 pmid:26669709 pmcid:PMC4684001 fatcat:rraemqs2ozhg3c2q2mdjlgbciu