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TRACE: transcription factor footprinting using chromatin accessibility data and DNA sequence
2020
Genome Research
Transcription is tightly regulated by cis-regulatory DNA elements where transcription factors can bind. Thus, identification of transcription factor binding sites (TFBSs) is key to understanding gene expression and whole regulatory networks within a cell. The standard approaches used for TFBS prediction, such as position weight matrices (PWMs) and chromatin immunoprecipitation followed by sequencing (ChIP-seq), are widely used, but have their drawbacks including high false positive rates and
doi:10.1101/gr.258228.119
pmid:32660981
pmcid:PMC7397869
fatcat:duzc7zeefbewris7ndyokcaz3q