Herbal drugs are bestowed with a number of properties due to which they are used in healthcare since ancient times. Several of them are reported to enhance immunity and natural resistance to disease and have recuperative power of the body. Such drugs are being consumed along with modern allopathic drugs particularly by geriatric patients. In recent years a number of herb-drug interactions have been reported some of which are serious in nature; for example consumption of Gingko biloba along with

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... anticoagulant warfarin may result in excessive bleeding or concomitant use of St. John wort and antidepressant drugs may result in serotonin syndrome. Through pharmacodynamics and pharmacokinetic processes the herb-drug interaction often results in potentiation of action of the drug by synergistic mechanism. Several such synergistic reports on herb-drug interactions in the area of antimicrobials, antineoplastics, antidiabetics, cardiovascular actives, antihepatotoxics, CNS actives etc are discussed.