Liver Proteins that are Sensitive to a Dioxin-Like Toxic Compound, Coplanar Polychlorinated Biphenyl, 3,3′,4,4′,5-Pentachlorobiphenyl

Yuji Ishii, Kazuta Oguri
2002 Journal of health science  
This review deals with the reducing ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) in protein levels of rat liver aldolase B, carbonic anhydrase III, class I alcohol dehydrogenase (ADH), glucose regulated protein 78 (GRP78), GRP94, calreticulin, and calnexin as well as the inducing ability in hepatic cytosolic 54 K protein (tentative selenium binding protein/acetaminophen binding protein homologue), heat shock protein 70
more » ... ock protein 70 (HSP70) and HSP90. These data could provide new aspects of dioxin's toxicity via marked changes in the levels of proteins with important functions.
doi:10.1248/jhs.48.97 fatcat:5i6etmuo3ze53oi2ggfwqcdlfu