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Effects of lnterleukin-4 or Stem Cell Factor on Mast Cell Mediator Release and Cytokine Gene Expression
1995
International Archives of Allergy and Immunology
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We have investigated the capacity of interleukin (IL)-4 or stem cell factor (SCF) to induce direct mediator release from rodent peritoneal mast cells, and also to induce or regulate cytokine gene expression in the human HMC-1 mast cell line. SCF, but not IL-4, induced low levels of serotonin release from mouse or rat peritoneal mast cells; rat mast cells acquired enhanced responsiveness to SCF during culture. IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several
doi:10.1159/000236961
pmid:7542063
fatcat:h42p3jdf25eyhpgoxncfmgcnhi