Photo-degradation of amyloid β by a designed fullerene–sugar hybrid

Yasunori Ishida, Shuho Tanimoto, Daisuke Takahashi, Kazunobu Toshima
2010 MedChemComm  
General Methods for Chemical Synthesis. 1 H NMR and 13 C NMR spectra were recorded on a JEOL ECA-500 (500 MHz) spectrometer using trimethylsilane as the internal standard, unless otherwise noted. ESI-TOF Mass spectra were measured on a Waters LCT premier XE. Silica gel TLC and column chromatography were performed using Merck TLC 60F-254 (0.25 mm) and Silica Gel 60 N (spherical, neutral) (Kanto Chemical Co., Inc.), respectively. Air-and/or moisture-sensitive reactions were carried out under an
more » ... gon atmosphere using oven-dried glassware. In general, organic solvents were purified and dried using appropriate procedures, and evaporation and concentration were carried out under reduced pressure below 30 °C, unless otherwise noted. Synthesis of 5. To a solution of 4 1 (503 mg, 1.09 mmol) in dry THF (22.0 mL) was added Pd-C (107 mg) Supplementary Material (ESI) for Medicinal Chemistry Communications This journal is
doi:10.1039/c0md00075b fatcat:dg2btwhz2fbfzpx6mmhq5m73ze