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Before acquiring their mature state, cochlear hair cells undergo a series of changes in expression of ion channels. How this complex mechanism is achieved is not fully understood. Tmprss3, a type II serine protease expressed in hair cells, is required for their proper functioning at the onset of hearing. To unravel the role of Tmprss3 in the acquisition of mature K 1 currents, we compared their function by patch-clamp technique in wild-type Tmprss3 WT and Tmprss3 Y260X -mutant mice.doi:10.1093/hmg/dds532 pmid:23255163 fatcat:uub6kysmlfaxhidqyoiqrf77am