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Motivation: High-throughput sequencing (HTS) technologies are transforming the study of genomic variation. The various HTS technologies have different sequencing biases and error rates, and while most HTS technologies sequence the residues of the genome directly, generating base calls for each position, the Applied Biosystem's SOLiD platform generates dibase-coded (color space) sequences. While combining data from the various platforms should increase the accuracy of variation detection, todoi:10.1093/bioinformatics/btq184 pmid:20529926 pmcid:PMC2881369 fatcat:qnejbeht3rhyzh2ivyewzoftau