Rapid Emergence of Appetite and Hunger Resulting in Weight Gain and Improvement of Eating Disorder Symptomatology during and after Short-Term Off-Label Metreleptin Treatment of a Patient with Anorexia Nervosa

Gertraud Gradl-Dietsch, Gabriella Milos, Martin Wabitsch, Rebecca Bell, Franziska Tschöpe, Jochen Antel, Johannes Hebebrand
Off-label treatment of a 15-year-old female patient with anorexia nervosa (AN) with human recombinant leptin (metreleptin) for nine days was associated with self-reported increments of appetite and hunger resulting in rapid weight gain and substantial improvement of eating disorder cognitions and of depression. The results further substantiate the effects of metreleptin on both AN and depression. We contrast these results with the widespread view that leptin is an anorexigenic hormone.
more » ... d controlled trials are warranted to confirm the described effects.
doi:10.5167/uzh-229932 fatcat:ibflo43dj5crjhpuqtnjmx2qo4