Neuroscience and accelerator mass spectrometry

Magnus Palmblad, Bruce A. Buchholz, Darren J. Hillegonds, John S. Vogel
2005 Journal of Mass Spectrometry  
Accelerator mass spectrometry (AMS) is a mass spectrometric method for quantifying rare isotopes. It has had great impact in geochronology and archaeology and is now being applied in biomedicine. AMS measures radioisotopes such as 3 H, 14 C, 26 Al, 36 Cl and 41 Ca, with zepto-or attomole sensitivity and high precision and throughput, enabling safe human pharmacokinetic studies involving: microgram doses, agents having low bioavailability, or toxicology studies where administered doses must be
more » ... pt low (<1 µg/kg). It is used to study long-term pharmacokinetics, to identify biomolecular interactions, to determine chronic and low-dose effects or molecular targets of neurotoxic substances, to quantify transport across the blood-brain barrier and to resolve molecular turnover rates in the human brain on the timescale of decades. We will here review how AMS is applied in neurotoxicology and neuroscience.
doi:10.1002/jms.734 pmid:15706618 fatcat:hyyumza6enenra5znurxca3tdy